Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

11 September 2021 0 By Bambam

Nature, Published online: 06 September 2021; doi:10.1038/s41586-021-03886-5

Cas7-11—the fusion of a putative Cas11 domain and four Cas7 subunits—cleaves RNA without detectable non-specific activity and, when optimized for RNA knockdown and editing in mammalian cells, has no effects on cell viability.